Neurotoxicity Services
Neurotoxicity is a major cause of compound attrition during drug discovery and development. Subtle effects on neuronal excitability or network function can remain undetected until late stages, leading to costly delays or safety concerns.
ChanPharm provides mechanistically driven neurotoxicity assessment services based on advanced electrophysiology and neuronal network analysis, enabling early detection of functional CNS liabilities and informed decision-making.
What We Offer
Our neurotoxicity services are designed to identify functional effects on neurons and neuronal networks, supporting safer and more efficient CNS and non-CNS drug development.
- Early detection of neurotoxic liability
- Mechanistic insight into neuronal effects
- Support for compound prioritization and optimization
Neuronal Models & Experimental Formats
Cellular Models
- Human iPSC-derived neurons
- Rodent or human neuronal cultures
- Ion channel-expressing neuronal cell models
Experimental Formats
- Single-neuron recordings
- Neuronal monolayers
- 2D neuronal networks
- Long-term cultured neuronal networks
Methods & Data
Single-Cell Electrophysiology
- Resting membrane potential
- Action potential firing properties
- Ion channel current characteristics
- Changes in neuronal excitability
MEA-Based Network Readouts
- Spike rate and burst frequency
- Network synchrony
- Functional connectivity
- Detection of abnormal or epileptiform activity
Functional Assessment
- Dose-dependent effects on neuronal activity
- Reversibility and recovery
- Time-dependent neurotoxicity
Technologies
Our neurotoxicity services are supported by validated electrophysiology platforms widely used in neuroscience research.
Patchliner — Nanion Technologies
Automated patch clamp for neuronal ion channel studies.
The Patchliner enables functional assessment of ion channel activity in neuronal systems. It provides automated whole-cell recordings from neurons and neuronal cell lines, allowing for the evaluation of compound effects on neuronal excitability and ion channel function.
Best suited for: Neuronal ion channel screening, medium-throughput neurotoxicity assessment, functional profiling
NANION TECHNOLOGIES MEDIUM THROUGHPUT
Manual Patch Clamp
Detailed characterization of neuronal excitability and firing properties.
Conventional whole-cell electrophysiology systems provide high-resolution recordings of neuronal activity. This gold-standard approach allows for detailed analysis of action potential properties, firing patterns, and synaptic responses in individual neurons.
Best suited for: Detailed neuronal characterization, action potential analysis, synaptic transmission studies
GOLD STANDARD HIGH RESOLUTION
MEA Systems — Multi Channel Systems (MCS)
Long-term, non-invasive recordings of neuronal network activity.
Multi-Electrode Array (MEA) technology enables simultaneous recording from multiple electrodes in neuronal networks over extended periods. This approach captures emergent network properties, including synchronization, burst dynamics, and functional connectivity that cannot be observed at the single-cell level.
Best suited for: Network-level neurotoxicity assessment, seizure liability detection, chronic exposure studies
MCS NETWORK PHYSIOLOGY